There are a few ways to perform Linear Regression(OLS) in Python.
Here is a short list of them:
1: > pandas.ols(y, x)
2: > pandas.stats.api.ols(y ,x)
3: > scipy.stats.linregress(x, y)
4: > import statsmodels.formula.api as smf
> results = smf.ols('Close ~ Open + Volume', data = df) # df is a DataFrame
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